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Grant Community.com Catalog of Federal Domestic Assistance Program Descriptions |
CATALOG OF FEDERAL DOMESTIC
ASSISTANCE
93.853: Extramural Research Programs in the Neurosciences and
Neurological Disorders
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| PROGRAM AND AWARD | FINANCIAL AND INFORMATION CONTACTS |
| ELIGIBILITY REQUIREMENTS | FINANCIAL AND ADMINISTRATIVE INFO. |
| APPLICATION AND AWARD PROCESS | INFORMATION CONTACTS |
| RELATED PROGRAMS | ASSISTANCE CONSIDERATIONS |
| PROGRAM ACCOMPLISHMENTS | POST ASSISTANCE REQUIREMENTS |
Applicant Eligibility: Research Grants: Any public, private, nonprofit, or for-profit institution is eligible to apply. For-profit institutions are not eligible for Institutional National Research Service Awards but are eligible for Individual NRSAs. All proposals are reviewed for scientific merit, for evaluation of the qualifications of the investigators, for adequacy of the research environment, and for significance of the problem. Approved proposals compete for available funds. All Career Development Program awardees must be citizens or have been admitted to the United States for permanent residence. Candidates must be nominated for the program by a nonfederal public or private nonprofit institution located in the United States, its possessions or territories. Awardees for RENS must have been accepted by a sponsoring institution, had previous training and experience in neurological science, an interruption in their careers for a period of at least three years and not more than 8 years, and be citizens or non-citizen nationals of the United States. Awardees for the Ernest Everett Just Award must be nominated for the program by an historically Black college or university, must have doctoral degree in basic or clinical science and at least one year of postdoctoral experience in a faculty or research position, and must be citizens or non-citizen nationals of the United States. Awardees for the Collaborative Neurological Sciences Award must be from a predominantly minority institution and must have a doctoral degree in a basic or clinical science area. To be eligible, postdoctoral NRSA trainees or fellows must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D. Eng., or equivalent domestic or foreign degree). SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the entire research must be performed in the United States. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which "partner" with a research institution in cooperative research and development. At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.
Beneficiary Eligibility: Health professionals, graduate students, health professional students, scientists, and researchers.
Credentials/Documentation: Research grants are awarded to an institution in the name of an individual investigator. Persons qualified to carry out research related to the extramural programs described above may apply for funds to support their investigations. Mentored Career Program training must be conducted under the direction of a competent sponsor. National Research Service Awards: Individual NRSA Fellowships for postdoctoral training: the candidate's academic record, research experience, citizenship, institutional sponsorship, and the proposed area and plan of training must be included in the application. Institutional Training Grants for predoctoral and postdoctoral training: The applicant institution must show the objectives, methodology and resources for the research training program; the qualifications and experience of directing staff; the criteria to be used in selecting individuals for stipend support; and a detailed budget and justification for the amount of grant funds requested. Costs will be determined in accordance with OMB Circular No. A-87 for State and local governments. For-profit organizations' costs are determined in accordance with Subpart 31.2 of the Federal Acquisition Regulations. For other grantees, costs will be determined in accordance with HHS Regulations 45 CFR, Part 74, Subpart Q. For SBIR and STTR grants, the applicant organization (small business concern) must present in a research plan an idea that has potential for commercialization and furnish evidence that scientific competence, experimental methods, facilities, equipment, and funds requested are appropriate to carry out the plan. Grant forms PHS 6246-1 and PHS 6246-2 are used to apply for SBIR Phase I and Phase II, respectively. Grant forms PHS 6246-3 and PHS 6246-4 are used to apply for STTR Phase I and Phase II, respectively.
Preapplication Coordination: Research grant applications exceeding $500,000 direct costs in any yearly budget period will not be accepted unless the NINDS has agreed to accept the application prior to submission. This program is excluded from coverage under E.O. 12372.
Application Procedure: For regular research grants and Institutional NRSAs request regular grant application forms PHS 398 (Rev. April 98) from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Phone: (301) 435-0714, E-mail: grantsinfo@nih.gov, Website: grants.nih.gov/grants/forms.htm. Complete application forms and return to the Center for Scientific Review, National Institutes of Health, Rockledge II, Room 1040, 6701 Rockledge Drive, Bethesda, MD 20892-7710. Phone: (301) 435-0715. Research Fellowships: Prior to formal application, a candidate must be accepted at an institution and have a sponsor who will supervise the training. Fellows may be sponsored by a (domestic or foreign) private or public institution. Application form 416-1 (Rev. 12/98) should be used for this program. Application forms and information concerning current areas of science being supported under the Research Fellowship Award Program should be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Phone: (301) 435-0714, e-mail: grantsinfo@nih.gov Website: grants.nih.gov/grants/funding/416/phs416.htm. Application forms for Individual or Institutional NRSAs and information concerning the areas of science being supported may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Phone: (301) 435-0714, E- mail: grantsinfo@nih.gov, Website: grants.nih.gov/grants/forms.htm and should be submitted to the Center for Scientific Review, National Institutes of Health, Rockledge II, Room 1040, 6701 Rockledge Drive, Bethesda, MD 20892- 7710. Phone: (301) 435-0715. This program is subject to the provisions of 45 CFR, Part 92 for State and local governments and OMB Circular No. A-110 for nonprofit organizations. Grant forms PHS 6246-1 and PHS 6246-2 are used to apply for SBIR Phase I and Phase II, respectively. SBIR and STTR Grant Solicitations and SBIR Contract Solicitation may be obtained electronically through the NIH's "Small Business Funding Opportunities" home page at http//grants.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of these publications are produced. Subject to availability, they may be obtained by contacting the NIH support services contractor: phone: (301) 206-9385; fax: (301) 206-9722; E-mail: a2y@cu.nih.gov. The Solicitations include submission procedures, review considerations, and grant application or contract proposal forms. SBIR and STTR grant applications should be submitted to the Center for Scientific Review, 6701 Rockledge Drive, Room 1040 - MSC 7710, Bethesda, MD 20892-7710.
Award Procedure: Research Grant and Training Program applications are reviewed initially by technical panels, composed of nongovernment scientific authorities, and by the National Advisory Neurological Disorders and Stroke Council composed of 18 leaders in medical science, education, and public affairs. Approved applications will compete on a merit basis for available funds. Formal award notices are transmitted to the grantee or awardee. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research.
Deadlines: All new research grant and career program applications, plus all (new, competing continuation, supplemental or revised) program project and center grant applications: February 1, June 1, and October 1. All competing continuation, supplemental and revised research grant and career program grant applications: March 1, July 1 and November 1. Individual NRSA applications: April 5, August 5, and December 5. Institutional NRSAs: May 10. SBIR: April 15, August 15, and December 15. STTR: April 1, August 1, and December 1.
Range of Approval/Disapproval Time: Research grants: About 6 to 9 months. Career program: From 6 to 9 months. SBIR/STTR applications: About 7-1/2 months. Institutional Training Grants: From 6 to 12 months.
Appeals: A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute, and subsequently, the P.I. and applicant institution may appeal to the NINDS appeals officer. A description of the NIH Peer Review Appeal procedures is available on the NIH home page grants.nih.gov/grants/guide/notice-files/not97-232.html.
Renewals: By application and review in same manner as new applications. Research Career Awards may not be renewed.
Criteria for Selecting Proposals: The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation, originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget requested for the work proposed; (7) the adequacy and suitability of the facilities and research environment; and 8) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment.
Examples of Funded Projects: Grants support research on neurological disorders such as: (1) cerebral palsy; (2) disorders of aging including Parkinson's, Huntington's, and Alzheimer's diseases and the dementias; (3) muscular, neuromuscular and demyelinating disorders; (4) neuroendocrine studies; neural aspect of learning and behavior; (5) nervous system tumors, and infectious diseases of the central nervous system. Recently funded applications include studies designed to result in advances for a group of useful glycosidases, as well as mechanistic information for the activator protein that is required for lysosomal degradation of GM2, a glycosphingolipid involved in Tay-Sachs disease. Another study focuses on mechanisms of synapse assembly, specifically the role of membrane associated quanylate kinases in the clustering and targeting of ion channels and receptors at the synapse. One example of the long range goal of a successful competing renewal application is to provide a better understanding of the mechanisms of movement of intracellular organelles along microtubules. Such movement plays a role in the process of fast axonal transport in nerve cells. The specific aims of another funded application are to assess environmental and genetic factors as determinants of hand preference, to determine whether measures of developmental stability can explain individual differences in phenotypic expressions of hand preference and to determine whether handiness is predictive of compromised immunological functioning and/or reproductive biology. A new project is aimed at addressing a series of fundamental issues regarding the mechanisms underlying the spread of synaptic modifications in neural networks. Another series of studies will take advantage of newly developed behavioral procedures and selective ibotenic acid lesions to compare the effects of lesioning hippocampus, subiculum, entorhinal cortex, and perirhinal cortex on learning and memory. Included in this effort are multi-disciplinary clinical research centers on Parkinson's disease, stroke, head and spinal cord injury, epilepsy, and demyelinating disorders, as well as program projects and a large number of individual grants. In head and spinal cord injury research studies, particular emphasis is given to the biomedical events and metabolism following injuries, with a view toward both salvaging damaged tissue and also creating conditions in which regeneration of injured nerve cells can take place. The clinical research program sponsors clinical trials to evaluate various therapeutic approaches to head and spinal cord injury, epilepsy, multiple sclerosis and other neurologic and neuromuscular disorders. The effects of systemic cancer on the central nervous system are studied, as part of the brain and spinal cord tumor research effort.
Range and Average of Financial Assistance: Research grants: $17,000 to $5,800,000; $400,000. Career Program - Clinical Investigator Development Awards: $13,300 to $115,000; $101,600. Research Career Development Awards: $33,100 to $133,100; $86,300. National Research Service Awards - Institutional: $43,600 to $334,600; $155,800; Individual: $20,000 to $37,012; $29,200. SBIR: Phase I about $100,000; Phase II not to exceed $750,000. STTR: Phase I about $100,000; Phase II not to exceed $500,000. (The SBIR and STTR dollars are guidelines, not limits.) the 93.854 Range and Average of Financial Assistance: Research Grants: $21,000 to $1,400,000; $218,000. Research Career Development Awards: $21,800 to $127,000; $95,000; National Research Service Awards - Institutional: $26,000 to $238,000; $133,000. Individual: $25,000 to $37,012; $29,000. SBIR: Phase I - about $100,000; Phase II - about $750,000. STTR: Phase I -about $100,000; Phase II - about $500,000. (The SBIR and STTR dollars are guidelines not limits.)
None.
In fiscal year 1999, there were 1925 competing research applications and of that number, 676 awards were made; of 373 competing NRSA applications, 156 awards were made. It is estimated that 700 competing research grants and 156 NRSAs will be made in fiscal year 2000. For fiscal year 2001, it is estimated that 487 competing research grants and 160 NRSAs will be made.
Federal Agency: NATIONAL INSTITUTES OF HEALTH, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Type of Assistance: Project Grants.
Obligations: (Extramural Research) FY 99 $779,597,000; FY 00 est $901,961,000; and FY 01 est $950,434,000.
Budget Account Number: 75-0886-0-1-552.
Authorization: Public Health Service Act, Sections 301, 405,408, 457, 458, 459, and 487, Public Law 78-410, as amended, 42 U.S.C. 241; 42 U.S.C. 284; 42 U.S.C. 284c; 42 U.S.C. 285j; 42 U.S.C. 285j-7; 42 U.S.C. 285L-2; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.
Regulations, Guidelines, and Literature: 42 CFR 52; 42 CFR 66; 45 CFR 74; Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.
Regional or Local Office: Not applicable.
Headquarters Office: Training, Career Development and Referral Office, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Blvd., Suite 2222B, Bethesda, MD 20892. Phone: (301) 496-4188. Program Contacts: Dr. William Heetderks, Repair and Plasticity, phone: (301) 496-1447; Dr. Audrey Penn, Neural Environment, phone: (301) 496-3167; Dr. John Marler, Neurodegeneration, phone: (301) 496-9135; Dr. Deborah Hirtz, Neurodevelopment, phone: (301) 496-5821; Dr. Cheryl Kitt, Systems & Cognition Neuroscience: Synapses & Circuits, phone: (301) 496-9964; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Neurosciences Center, 6001 Executive Blvd., Bethesda, MD 20892. Grants Management Contact: Ms. Joellen Harper, Grants Management Officer, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Blvd., Bethesda, MD 20892. Phone: (301) 496-9231. Contracts Management Contact: Mr. Kirk Davis, Contracts Management Officer, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Blvd., Bethesda, MD 20892. Phone: (301) 496-1813.
(See Appendix IV for more contact info.)
Formula and Matching Requirements: This program has no statutory formula or matching requirements.
Length and Time Phasing of Assistance: Research grant awards are made for a 12-month period with recommendation of up to 4 years of additional support. Career Program awards provide support for 3 to 5 years. Training Program awards are usually for a 12-month period with recommendation of additional support of up to a total of 5 years for predoctoral training and no more than 3 years for postdoctoral training. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years.
Uses and Use Restrictions: Research grants may be used to provide salaries, equipment, supplies, travel and other expenses for research. The grantee institution is obliged to expend grant funds prudently for the purposes stated in the application and award document. National Research Service Awards (NRSAs) are made directly to individuals for research training in specified biomedical shortage areas or to institutions, to enable them to make NRSAs to individuals selected by them. Each individual who receives a NRSA is obligated upon termination of the award to comply with service and payback provisions. Career Development Awards such as the Independent Scientist Awards provide support for newly independent scientists with health related degrees who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Mentored Clinical Research Scientist Development Awards provide support for clinically trained health professionals who need an additional period of sponsored research experience as a way to gain expertise in a research area new to the candidate or in an area that would demonstrably enhance the candidate's scientific career. The Mentored Research Scientist Development Award are of two types: Re-Entry into the Neurological Sciences (RENS) which are made to women and men who have been out of neuroscience research for at least three years to give them an opportunity to re-establish their skills as independent neuroscientists, and the Ernest Everett Just Faculty Research Career Development Award which contribute to the further career development of faculty members at historically Black colleges and universities. The Mentored Patient-Oriented Research Career Development Award provide support for a period of supervised study and research for clinically trained professionals who have the potential to develop into productive clinical investigators. The Mid-career Investigator Award in Patient-Oriented Research provide support for clinicians to allow them protected time to devote to patient-oriented research and to act as mentors for beginning clinical investigators. The Collaborative Neurological Sciences Award is to develop and promote competitive neurological science research programs at predominantly minority institutions with grantees from research intensive institutions who have NIH grant support to conduct neurological science research. SBIR Phase I grants (of about 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research efforts initiated in Phase I that are likely to result in commercial products or processes. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential of Phase II application. Grant funds may be expended only for the purpose stated in the application and award document. The NINDS participates in the NIH SBIR/STTR "fast track" initiative.
Reports: Research Grants: Annual and final progress reports, including a description of results, positive and negative, and a list of any publications. Career Program: Awardee submits annual progress report. Termination notice, PHS 416-7, must be submitted upon completion of NRSA training. Reports are required after termination of National Research Service Awards to ascertain compliance with the service and payback provisions. A Financial Status Report must be submitted within 90 days after the close of each budget period for which an award has been issued.
Audits: In accordance with the provisions of OMB Circular No. A-133, (Revised, June 24, 1997), "Audits of States and Local Governments," and Non-Profit Organizations," nonfederal entities that receive financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $300,000 or more in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials.
Records: Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last Financial Status Report for the report period.
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Last Updated, November, 2000
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